Also known as childhood-onset diabetes, type 1 diabetes requires regular blood sugar tests and medical intervention. According to research or other evidence, the following self-care steps may be helpful.
Fight back with fiber
Under a doctor's supervision, stabilize your blood sugar by eating fiber from whole grains, beans (legumes), vegetables, and fruit, and consider using a fiber supplement such as psyllium or guar gum
Go for the chromium
Under the supervision of a doctor, take 200 mcg a day of this essential trace mineral to improve glucose tolerance
Protect with alpha lipoic acid
Protect against diabetic complications, such as nerve and kidney damage, by taking 600 to 1,200 mg of this supplement per day
About This Condition
Diabetes mellitus is an inability to metabolize carbohydrates resulting from inadequate insulin production or utilization. Other forms of diabetes (such as diabetes insipidus) are not included in this discussion.
There are two types of diabetes mellitus, type 1 and type 2. This article concerns type 1 diabetes, which has also been called childhood-onset diabetes or insulin-dependent diabetes. In type 1 diabetes, the pancreas cannot make the insulin needed to process glucose. Natural therapies cannot cure type 1 diabetes, but they may help by making the body more receptive to insulin supplied by injection. It is particularly critical for people with type 1 diabetes to work carefully with the doctor prescribing insulin before contemplating the use of any herbs, supplements, or dietary changes mentioned in this article. Any change that makes the body more receptive to insulin could require critical changes in insulin dosage that must be determined by the treating physician.
People with diabetes cannot properly process glucose, a sugar the body uses for energy. As a result, glucose stays in the blood, causing blood glucose to rise. At the same time, however, the cells of the body can be starved for glucose. People with diabetes are at high risk for heart disease, atherosclerosis, cataracts, retinopathy, stroke, poor wound healing, infections, and damage to the kidneys and nerves.
Healthy Lifestyle Tips
Everyone with diabetes aged 6 months and older should get a seasonal flu shot. Close household contacts and out-of-home caregivers of people with diabetes should also get the vaccines. People can receive both flu shots at the same time.1
Unusually rapid weight gain in infancy has been associated with a one-and-a-half-fold increase in the risk of developing type 1 diabetes in childhood.2 Being overweight also increases the need for insulin. Therefore, people with type 1 diabetes should achieve and maintain appropriate body weight.
People with type 1 diabetes who engage in regular exercise require less insulin.3 However, in the short term, exercise can induce low blood sugar or even occasionally increased blood sugar.4 Moreover, a preliminary study has shown that long-term physical activity was not associated with control of blood glucose in people with type 1 diabetes.5 Therefore, people with type 1 diabetes should never begin an intensive exercise program without consulting a healthcare professional.
The American Diabetes Association (ADA) recommends that people with diabetes limit their daily alcohol consumption to one drink for women and two drinks for men.6 Similar to research on healthy people, preliminary studies in adults with diabetes find reduced risk of heart disease with light to moderate drinking.7 Drinking alcohol with type 1 diabetes can result in hypoglycemia or hyperglycemia, depending on the circumstances, but moderate amounts of alcohol ingested with food does not affect blood glucose levels.8 People with diabetes who drink two or more drinks per day were reported to have a high risk for eye damage in one preliminary study,9 but another, larger study found no association between alcohol use and eye damage.10
People with diabetes who smoke are at higher risk for kidney damage,11heart disease,12 and other diabetes-linked problems. Smokers are also more likely to develop diabetes,13 so it's important for diabetic smokers to quit.
Most healthcare providers agree on the necessity of self-monitoring of blood glucose (SMBG) by people with type 1 diabetes. Advocates of SMBG, such as the ADA, have observed that SMBG by people with diabetes has revolutionized management of the disease, enabling them to achieve and maintain specific goals.14 These observations are well-supported in the medical literature.15 Detractors point out that indiscriminate use of self-monitoring is of questionable value and adds enormously to healthcare costs.16 The ADA acknowledges that accuracy of SMBG is instrument- and technique-dependent. Errors in technique and inadequate use of control procedures have been shown to lead to inaccurate test results.17 Nevertheless, it is likely that self-monitoring of blood glucose, if used properly, can have a positive effect by increasing patient involvement in overall diabetes care.18 Pharmacists and healthcare practitioners can teach people with diabetes certain skills that will enhance their ability to properly self-manage blood glucose.
Acupuncture may be helpful in the treatment of diabetes, or complications associated with diabetes. In a preliminary trial, 77% of people suffering from diabetic nerve damage (neuropathy) experienced significant reduction in pain following up to six acupuncture treatments over a ten-week period. Many were also able to reduce pain medications, but no long-term change in blood-sugar control was observed.19 Bladder control problems, a complication of long-term diabetes, responded to acupuncture treatment with a significant reduction in symptoms in both controlled and uncontrolled trials.20, 21
The right diet is the key to managing many diseases and to improving general quality of life. For this condition, scientific research has found benefit in the following healthy eating tips.
Add some olive oil
Extra virgin olive oil is a good source of monounsaturated fat. Increasing monounsaturated fats relative to other dietary fats is associated with better blood sugar control and cholesterol levels.
Changing the overall percentage of calories from fat and carbohydrates in the diets of people with type 1 diabetes is often difficult. However, it is possible to modify the quality of the dietary fat. In adolescents with type 1 diabetes, increasing monounsaturated fats relative to other dietary fats is associated with better control over blood sugar and cholesterol levels.22 The best way to incorporate monounsaturates into the diet is to use olive oil, especially extra virgin olive oil, which has the highest antioxidant values.
Fight back with fiber
Studies have suggested that a high-fiber diet, especially when combined with a low-glycemic-index diet, improves blood sugar control.
Older studies suggested that including 30 grams per day or more of fiber helps control blood sugar in type 1 diabetes.23 However, a more recent controlled study of people with well-controlled type 1 diabetes on intensive insulin regimens found no important benefits from consuming a high-fiber diet.24 In another trial, a low-glycemic-index diet containing 50 grams per day of fiber improved blood sugar control and helped prevent hypoglycemic episodes in a group of people with type 1 diabetes taking two or more insulin injections per day.25 Consuming more fiber may not be as helpful in type 1 diabetes when modern intensive insulin regimens are used, but eating high-fiber foods is recommended for its many other health benefits.26
When taken with meals, high-fiber supplements such as guar gum reduced the rise in blood sugar following meals in people with type 1 diabetes.27, 28 More research is needed to determine if regular use of fiber supplements benefits long-term blood sugar control in type 1 diabetes.
Keep an eye on the GI
Whole grains, beans, vegetables, and fruit help keep blood sugar levels stable because their low glycemic index does not cause blood sugar to spike.
Eating carbohydrate-containing foods, whether high in sugar or high in starch (such as bread, potatoes, processed breakfast cereals, and rice), temporarily raises blood sugar and insulin levels.29 The blood sugar–raising effect of a food, called its “glycemic index,” depends on how rapidly its carbohydrate is absorbed. Many starchy foods have a glycemic index similar to table sugar (sucrose).30Beans, peas, fruit, and oats have low glycemic indexes, despite their high carbohydrate content, due mostly to the health-promoting effects of soluble fiber. Controlled studies have found that people with type 1 diabetes who follow a low-glycemic-index diet have better long-term control over their blood sugar levels compared with those following a high-glycemic-index diet.31 However, other studies find similar benefits from training patients to adjust their insulin doses according to the total carbohydrate content of each meal or snack (“carbohydrate counting”).32 People with type 1 diabetes should always discuss changes in their diet with their treating physician.
Most doctors recommend that people with diabetes eat less sugary foods like snacks and processed foods and replace these foods with high-fiber, whole foods.
Diabetes disrupts the mechanisms by which the body controls blood sugar. Until recently, health professionals have recommended sugar restriction to people with diabetes, even though short-term high-sugar diets have been shown, in some studies, not to cause blood sugar problems in people with diabetes.33, 34, 35 Currently, the American Diabetic Association (ADA) guidelines do not prohibit the use of moderate amounts of sugar,36 as long as blood levels of glucose, triglycerides, and cholesterol are maintained within normal levels.
Most doctors recommend that people with diabetes cut intake of sugar from snacks and processed foods, and replace these foods with high-fiber, whole foods. This tends to lower the glycemic index of the overall diet and has the additional benefit of increasing vitamin, mineral, and fiber intake. Other authorities also recommend lowering the glycemic index of the diet to improve the control of diabetes.37
Try a vegan diet
A vegan diet has been shown to improve diabetic nerve damage, while a low-protein diet has been shown to reduce diabetic kidney damage and may also improve glucose tolerance.
When people with diabetic nerve damage (neuropathy) switch to a vegan diet (no meat, dairy, or eggs), improvements have been reported after several days.38 In one trial, pain completely disappeared in 17 of 21 people.39 Fats from meat and dairy may also contribute to heart disease, the leading killer of people with diabetes. Vegetarians also eat less protein than do meat eaters. Reducing protein in the diet has lowered kidney damage caused by diabetes and may also improve glucose tolerance in type 1 diabetes.40, 41, 42 Switching to either a high- or low-protein diet should be discussed with a doctor.
Stay tuned about milk
The relationship between cows' milk and type 1 diabetes remains unclear, although there is some evidence that drinking milk may increase the risk of developing type 1 diabetes.
Should children avoid milk to prevent type 1 diabetes? The relationship between cows' milk and type 1 diabetes remains unclear, although there is some evidence that milk consumption might increase the risk of developing type 1 diabetes. Worldwide, children whose dietary energy comes primarily from dairy or meat products have a significantly higher chance of developing type 1 diabetes than do children whose dietary energy comes primarily from vegetable sources.43 Countries with high milk consumption have a high risk of type 1 diabetes.44 Animal research also indicates that avoiding milk affords protection from type 1 diabetes.45 Milk contains a protein related to a protein in the pancreas, the organ that produces insulin. Some researchers believe that drinking milk may cause children who are allergic to milk to make antibodies that attack the pancreas, causing type 1 diabetes.46, 47 Several studies have linked cows’ milk consumption to the occurrence of type 1 diabetes in children.48, 49, 50, 51 However, other studies have failed to find such a link.52, 53 One study even reported a protective effect of higher intake of dairy products on diabetes risk in children.54 One reason for the conflicting results of the research may be that different genetic strains of cows’ milk protein (casein) are associated with different levels of risk.55
Immune-system problems in people with type 1 diabetes have been tied to other allergies as well,56 and the importance of focusing only on the avoidance of dairy products remains unclear.57 Preliminary studies have found that early introduction of cows’ milk formula feeding increases the risk of developing type 1 diabetes, although contradictory results have also been published.58, 59 A study of Finnish children (including children with diabetes) showed that early introduction of cows’ milk formula feeding (before three months of age vs. after three months of age) was associated with increased risk of type 1 diabetes.60 This research supports abstaining from dairy products in infancy and possibly in early childhood, particularly for children with a family history of type 1 diabetes. Recent research also suggests a possible link between milk consumption in infancy and an increased risk of type 2 (non-insulin-dependent) diabetes.61
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by some in the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
3 StarsReliable and relatively consistent scientific data showing a substantial health benefit.
2 StarsContradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 StarFor an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Alpha Lipoic Acid
600 to 1,200 mg a day
Supplementing with alpha lipoic acid may protect against diabetic complications, such as nerve and kidney damage.
Alpha lipoic acid is a powerful natural antioxidant. Preliminary and double-blind trials have found that supplementing with 600 to 1,200 mg of lipoic acid per day improves the symptoms of diabetic nerve damage (neuropathy).62, 63, 64, 65 In a preliminary study, supplementing with 600 mg of alpha-lipoic acid per day for 18 months slowed the progression of kidney damage in people with type 1 diabetes.66
Cayenne Topical (Diabetic Neuropathy)
Apply an ointment containing 0.025 to 0.075% capsaicin four times per day to areas of nerve pain
Topically applied capsaicin (from cayenne) has been shown to relieve symptoms of diabetic neuropathy.
Double-blind trials have shown that topical application of creams containing 0.025 to 0.075% capsaicin (from cayenne [Capsicum frutescens]) can relieve symptoms of diabetic nerve damage (neuropathy).67, 68 Four or more applications per day may be required to relieve severe pain. This should be done only under a doctor’s supervision.
200 mcg daily
Chromium has been shown to help improve glucose tolerance in people with type 1 diabetes.
Chromium, a trace mineral that appears to increase the effectiveness of insulin, has been shown to improve glucose and related variables in people with many kinds of diabetes, including type 1 diabetes. Chromium may also lower levels of total , LDL cholesterol, and (risk factors for heart disease).69, 70 The typical amount of chromium used in research trials is 200 mcg per day. Supplementation with chromium or (a source of chromium) could potentially enhance the effects of drugs for diabetes (for example, insulin or other blood sugar-lowering agents) and possibly lead to hypoglycemia. Therefore, people with diabetes taking these medications should supplement with chromium or brewer's yeast only under the supervision of a doctor.
30 grams daily
Taking fiber supplements may help to stabilize your blood sugar.
When taken with meals, high-fiber supplements such as guar gum reduced the rise in blood sugar following meals in people with type 1 diabetes.71, 72 More research is needed to determine if regular use of fiber supplements benefits long-term blood sugar control in type 1 diabetes.
200 to 600 mg daily
People with type 1 diabetes tend to have low magnesium levels, supplementing with the mineral may reduce the risk of deficiency-related problems, such as eye damage and neuropathy.
People with type 1 diabetes tend to have low magnesium levels, and magnesium given orally or by injection partially overcomes the reduction in magnesium levels.73 In one preliminary trial, insulin requirements were lower in people with type 1 diabetes who were given magnesium.74 Diabetes-induced damage to the eyes is more likely to occur in magnesium-deficient people with type 1 diabetes.75 In magnesium-deficient pregnant women with type 1 diabetes, the lack of magnesium may even account for the high rate of spontaneous abortion and birth defects associated with type 1 diabetes.76 A double-blind trial found that giving 300 mg per day of magnesium to magnesium-deficient type 1 diabetics for five years slowed the development of diabetic nerve damage (neuropathy). The American Diabetes Association acknowledges strong associations between magnesium deficiency and insulin resistance but has not said magnesium deficiency is a risk factor.77 Many doctors, however, recommend that adults with diabetes and normal kidney function supplement with 200 to 600 mg of magnesium per day (those amounts would be lower for children).
Acetyl-L-Carnitine (Diabetic Neuropathy)
500 to 1,000 mg three times per day
Taking acetyl-L-carnitine may improve symptoms of diabetic neuropathy.
In a double-blind study of people with diabetic nerve damage (neuropathy), supplementing with acetyl-L-carnitine was significantly more effective than a placebo in improving subjective symptoms of neuropathy and objective measures of nerve function.78 People who received 1,000 mg of acetyl-L-carnitine three times per day tended to fare better than those who received 500 mg three times per day.
160 mg twice per day of an herbal extract containing 25% anthocyanosides
Bilberry may lower the risk of some diabetic complications, such as diabetic cataracts and retinopathy.
Bilberry may lower the risk of some diabetic complications, such as diabetic cataracts and retinopathy. One preliminary trial found that supplementation with a standardized extract of bilberry improved signs of retinal damage in some people with diabetic retinopathy.79
16 mg daily
Biotin may improve glucose levels and reduce pain from diabetic nerve damage.
Biotin is a B vitamin needed to process glucose. When people with type 1 diabetes were given 16 mg of biotin per day for one week, their fasting glucose levels dropped by 50%.80 Biotin may also reduce pain from diabetic nerve damage (neuropathy).81 Some doctors try 16 mg of biotin for a few weeks to see if blood sugar levels will fall.
800 mg per day of an herbal extract standardized for 25% gymnemic acids
Gymnema may help normalize blood sugar control in people with type 1 diabetes.
Test tube and animal studies have found several mechanisms by which gymnema may help normalize blood sugar control in diabetics.82 In a controlled trial with people with type 1 diabetes, 400 mg per day of gymnema extract reduced requirements for insulin.83 Whether the extract used in this study was standardized for active constituents is unclear. Recently, a preliminary trial found improved blood sugar levels after three months in a group of people with type 1 and type 2 diabetes who took 800 mg per day of an extract standardized for 25% gymnemic acids.84 Gymnema is not a substitute for insulin, but insulin amounts may need to be lowered in order to avoid hypoglycemia while taking gymnema.
0.25 mg per 2.2 lbs (1 kg) of body weight
Supplementing with L-carnitine may reduce cholesterol and triglyceride levels in people with diabetes.
L-carnitine is an amino acid needed to properly utilize fat for energy. When people with diabetes were given L-carnitine (0.5 mg per 2.2 pounds of body weight), high blood levels of fats—both cholesterol and triglycerides—dropped 25 to 39% in just ten days in one trial.85
20 grams fresh onion three times per day
Large amounts of onion have been shown to lower blood sugar levels in people with diabetes, possibly by blocking the breakdown of insulin in the liver.
Preliminary trials and at least one double-blind trial have shown that large amounts of onion can lower blood sugar levels in people with diabetes.86, 87, 88 The mechanism of onion’s blood sugar-lowering action is not precisely known, though there is evidence that constituents in onions block the breakdown of insulin in the liver. This would lead to higher levels of insulin in the body.89
25 mg daily, with 50 mg of vitamin B6 daily
People with type 1 diabetes may be deficient in vitamin B1. Supplementing with vitamin B1 may restore levels and improve symptoms of diabetic neuropathy.
Blood levels of vitamin B1 (thiamine) have been found to be low in people with type 1 diabetes.90 A controlled trial in Africa found that supplementing with both vitamin B1 (25 mg per day) and vitamin B6 (50 mg per day) led to significant improvement of symptoms of diabetic nerve damage (neuropathy) after four weeks.91 However, since this was a trial conducted among people in a vitamin B1–deficient developing country, these improvements might not occur in other people with diabetes. Another trial found that combining vitamin B1 (in a special fat-soluble form) and vitamin B6 plus vitamin B12 in high but variable amounts led to improvement in some aspects of diabetic neuropathy in 12 weeks.92 As a result, some doctors recommend that people with diabetic neuropathy supplement with vitamin B1, though the optimal level of intake remains unknown.
Consult a qualified healthcare practitioner
Taking vitamin B3 (as niacin or niacinamide) might prevent or limit the severity of type 1 diabetes in your family.
Taking large amounts of niacin (a form of vitamin B3), such as 2 to 3 grams per day, may impair glucose tolerance and should be used by people with diabetes only with medical supervision.93, 94
Some clinical trials have shown that niacinamide (another form of vitamin B3) supplementation might be useful in the very early stages of type 1 diabetes,95 though not all trials support this claim.96, 97, 98 Although an analysis of research shows that niacinamide does help preserve some function of insulin-secreting cells in people recently diagnosed with type 1 diabetes, the amount of insulin required for those given niacinamide has remained essentially as high as for those given placebo.99 A controlled trial found no beneficial effect of niacinamide supplementation (700 mg three times per day in addition to intensive insulin therapy) on pancreatic function and glucose tolerance in people newly diagnosed with type 1 diabetes.100
Some,101 but not all,102 reports suggest that healthy children at high risk for type 1 diabetes (such as the healthy siblings of children with type 1 diabetes) may be protected from the disease by supplementing with niacinamide. Parents of children with type 1 diabetes should consult their doctor regarding niacinamide supplementation as a way to prevent diabetes in their other children. Although the optimal amount of niacinamide is not known, recent evidence suggests that 25 mg per 2.2 pounds of body weight per day may be as effective as higher amounts.103
1,800 mg daily of of pyridoxine alpha-ketoglutarate or 50 mg daily pyridoxine
People with diabetes often have low vitamin B6 levels. Supplementing with the vitamin may restore levels and improve glucose tolerance.
Blood levels of vitamin B1 (thiamine) have been found to be low in people with type 1 diabetes.104 A controlled trial in Africa found that supplementing with both vitamin B1 (25 mg per day) and vitamin B6 (50 mg per day) led to significant improvement of symptoms of diabetic nerve damage (neuropathy) after four weeks.105 However, since this was a trial conducted among people in a vitamin B1–deficient developing country, these improvements might not occur in other people with diabetes. Another trial found that combining vitamin B1 (in a special fat-soluble form) and vitamin B6 plus vitamin B12 in high but variable amounts led to improvement in some aspects of diabetic neuropathy in 12 weeks.106 As a result, some doctors recommend that people with diabetic neuropathy supplement with vitamin B1, though the optimal level of intake remains unknown.107
Many people with diabetes have low blood levels of vitamin B6.108, 109 Levels are even lower in people with diabetes who also have neuropathy.110 In a trial that included people with type 1 diabetes, 1,800 mg per day of a special form of vitamin B6—pyridoxine alpha-ketoglutarate—improved glucose tolerance dramatically.111 Vitamin B6 may also reduce the amount of glycosylation, so taking adequate amounts of this vitamin may be beneficial for all people with diabetes.112
500 mg twice per day
Supplementing with vitamin C may benefit people with type 1 diabetes in several ways, including by reducing sorbitol levels, urinary protein loss, glycosylation, and eye damage.
People with type 1 diabetes appear to have low vitamin C levels.113 As with vitamin E, vitamin C may reduce glycosylation.114 Vitamin C also lowers sorbitol levels in people with diabetes.115 Sorbitol is a sugar that can accumulate inside the cells and damage the eyes, nerves, and kidneys of people with diabetes. Vitamin C supplementation (500 mg twice a day for one year) has significantly reduced urinary protein loss in people with diabetes. Urinary protein loss (also called proteinuria) is associated with poor prognosis in diabetes.116 Many doctors suggest that people with diabetes supplement with 1 to 3 grams per day of vitamin C. Higher amounts could be problematic, however. In one person, 4.5 grams per day was reported to increase blood sugar levels.117
One study examined antioxidant supplement intake, including both vitamins E and C, and the incidence of diabetic eye damage (retinopathy).118 A surprising finding was that people with extensive retinopathy had a greater likelihood of having taken vitamin C and vitamin E supplements. The outcome of this study, however, does not fit with most other published data and might simply reflect the fact that sicker people are more likely to take supplements in hopes of getting better. For the present, most doctors remain relatively unconcerned about the outcome of this isolated report.
Consult a qualified healthcare practitioner
Vitamin D is needed to maintain adequate insulin levels, and supplementing with it may reduce the risk of developing type 1 diabetes.
Vitamin D is needed to maintain adequate blood levels of insulin.119 Vitamin D receptors have been found in the pancreas where insulin is made and some, but not all preliminary evidence suggests that supplementation might reduce the risk of developing type 1 diabetes.120, 121 Vitamin D supplementation may also slow the decline of pancreatic function in people with newly diagnosed type 1 diabetes who have not yet suffered an extensive loss of pancreatic function.122 Not enough is known about optimal amounts of vitamin D for people with diabetes, and high amounts of vitamin D can be toxic. Therefore, people with diabetes considering vitamin D supplementation should talk with a doctor and have their vitamin D status assessed.
Vitamin E (Diabetic Retinopathy)
1800 IU daily
Supplementing with vitamin E may combat free radicals associated with diabetic retinopathy.
People with low blood levels of vitamin E are more likely to develop type 1 diabetes,123 but no studies have been done using vitamin E supplements to try to prevent type 1 diabetes. Animal and preliminary human data indicate that vitamin E supplementation may protect against diabetic eye damage and nephropathy,124, 125 serious complications of diabetes involving the eyes and kidneys, respectively, though no long-term trials in humans have confirmed this preliminary evidence. Glycosylation is an important measurement of diabetes; it refers to how much sugar attaches abnormally to proteins. Excessive glycosylation appears to be one of the causes of the organ damage that occurs in diabetes. Vitamin E supplementation has reduced the amount of glycosylation in many,126, 127, 128although not all, studies of people with type 1 diabetes.129, 130
Vitamin E (Diabetic Nephropathy)
900 to 1,800 IU daily
Vitamin E supplementation may protect against diabetic neuropathy.
People with low blood levels of vitamin E are more likely to develop type 1 diabetes,131 but no studies have been done using vitamin E supplements to try to prevent type 1 diabetes. Animal and preliminary human data indicate that vitamin E supplementation may protect against diabetic eye damage and nephropathy,132, 133 serious complications of diabetes involving the eyes and kidneys, respectively, though no long-term trials in humans have confirmed this preliminary evidence. Glycosylation is an important measurement of diabetes; it refers to how much sugar attaches abnormally to proteins. Excessive glycosylation appears to be one of the causes of the organ damage that occurs in diabetes. Vitamin E supplementation has reduced the amount of glycosylation in many,134, 135, 136although not all, studies of people with type 1 diabetes.137, 138
Consult a qualified healthcare practitioner
Supplementing with zinc may lower blood sugar levels and improve immune function in people with type 1 diabetes.
People with type 1 diabetes tend to be zinc deficient,139 which may impair immune function.140 Zinc supplements have lowered blood sugar levels in people with type 1 diabetes.141
Some doctors are concerned about having people with type 1 diabetes supplement with zinc because of a report that zinc supplementation increased glycosylation,142 generally a sign of deterioration of the condition. This trial is hard to evaluate because zinc supplementation increases the life of blood cells and such an effect artificially increases the lab test results for glycosylation. Until this issue is resolved, those with type 1 diabetes should consult a doctor before considering supplementation with zinc.
Refer to label instructions
Açaí is reported to be a traditional remedy for diabetes.
Açaí is reported to be a traditional remedy for diabetes. Although oxidative stress may contribute to diabetes143 and anthocyanins may improve insulin secretion,144 there is no published evidence that açaí has any effect on diabetes.
Refer to label instructions
Amylase inhibitors, when given with a starchy meal, can reduce the usual rise in blood sugar levels of people with diabetes.
Starch blockers are substances that inhibit amylase, the digestive enzyme required to break down dietary starches for normal absorption. Controlled research has demonstrated that concentrated starch blocker extracts, when given with a starchy meal, can reduce the usual rise in blood sugar levels of both healthy people and diabetics.145, 146, 147, 148, 149 While this effect could be helpful in controlling diabetes, no research has investigated the long-term effects of taking starch blockers for this condition.
Refer to label instructions
Asian ginseng is commonly used in traditional Chinese medicine to treat diabetes.
Asian ginseng is commonly used in Traditional Chinese Medicine to treat diabetes. It has been shown in test tube and animal studies to enhance the release of insulin from the pancreas and to increase the number of insulin receptors.150, 151 Animal research has also revealed a direct blood sugar–lowering effect of ginseng.152 However, no human trials have tested Asian ginseng in people with type 1 diabetes.
Refer to label instructions
Supplementing with CoQ10 may improve blood sugar metabolism.
Coenzyme Q10 (CoQ10) is needed for normal blood sugar metabolism. Animals with diabetes have been reported to be CoQ10 deficient. In one trial, blood sugar levels fell substantially in 31% of people with diabetes after they supplemented with 120 mg per day of CoQ7, a substance similar to CoQ10.153 In people with type 1 diabetes, however, supplementation with 100 mg of CoQ10 per day for three months neither improved glucose control nor reduced the need for insulin.154 The importance of CoQ10 supplementation for people with diabetes remains an unresolved issue, though some doctors recommend approximately 50 mg per day as a way to protect against possible effects associated with diabetes-induced depletion.
Evening Primrose Oil
See Learn More for details
Evening primrose oil has been associated with improved diabetic neuropathy. However, the principal investigator who conducted these clinical trials was found to have falsified research results, so whether EPO or GLA is of any value for neuropathy is still unknown.
Supplementing with 4 grams of evening primrose oil per day for six months has been found in double-blind research to improve nerve function and to relieve pain symptoms in people with diabetic nerve damage (neuropathy).155 However, the principal investigator who conducted these clinical trials was subsequently found by the professional conduct committee of the General Medical Council (United Kingdom) to have falsified the results of the research.156 Therefore, it is not clear whether evening primrose oil or GLA is of any value for patients with diabetic neuropathy.
Refer to label instructions
Fenugreek seeds are high in soluble fiber, which helps lower blood sugar by slowing down carbohydrate digestion and absorption.
Fenugreek seeds are high in soluble fiber, which helps lower blood sugar by slowing down carbohydrate digestion and absorption.157 Animal research suggests that fenugreek may also contain a substance that stimulates insulin production and improves blood sugar control.158, 159 In a controlled study in people with type 1 diabetes, incorporating powdered fenugreek seed into lunch and dinner meals (50 grams per meal) for ten days improved several measures of blood sugar control compared to a similar ten-day diet without added fenugreek.160
Refer to label instructions
Supplementing with fish oil may improve glucose tolerance and symptoms of diabetic neuropathy and nephropathy.
Glucose tolerance improves in healthy people taking omega-3 fatty acid supplements.161 And in one trial, people with diabetic nerve damage (neuropathy) and diabetic nephropathy experienced significant improvement when given 600 mg three times per day of purified eicosapentaenoic acid (EPA)—one of the two major omega-3 fatty acids found in fish oil supplements—for 48 weeks.162 However, controlled studies have found that fish oil supplementation increases cholesterol in people with type 1 diabetes.163, 164 Until the risk–benefit ratio of using fish oil is clarified, people with diabetes should feel free to increase their fish intake, but they should consult a doctor before taking fish oil supplements.
Refer to label instructions
The herb ginkgo may help prevent and treat early-stage diabetic nerve damage.
Ginkgo biloba extract may prove useful for prevention and treatment of early-stage diabetic nerve damage (neuropathy), though research is at best very preliminary in this area.165
Refer to label instructions
Glucomannan delays stomach emptying, leading to more gradual sugar absorption and possibly lowering insulin requirements for people with type 1 diabetes.
Glucomannan is a water-soluble dietary fiber derived from konjac root (Amorphophallus konjac). Glucomannan delays stomach emptying, leading to a more gradual absorption of dietary sugar. This effect can reduce the elevation of blood sugar levels that is typical after a meal.166 This could lower insulin requirements for type 1 diabetics, but no research has been done to test this possibility.
Refer to label instructions
Hibiscus is a traditional remedy in India for diabetes, and is supported by preliminary research.
Hibiscus is a traditional remedy in India for diabetes; this treatment is supported by preliminary studies from that country and by animal studies.167, 168 Hibiscus is usually taken as tea, 1 to 2 teaspoons (3 to 6 grams) of dried flower infused in to 1 cup (250 ml) of water three times per day.
Refer to label instructions
Supplementing with inositol may improve diabetic neuropathy.
Inositol is needed for normal nerve function. Diabetes can cause a type of nerve damage known as diabetic neuropathy. Certain measures of the severity of this condition have been reported to improve with inositol supplementation (500 mg taken twice per day);169 however, in other trials, inositol was ineffective.170
Refer to label instructions
People with diabetes may have low manganese levels, which can contribute to glucose intolerance. Supplementing with the mineral may help.
People with diabetes may have low blood levels of manganese.171 Animal research suggests that manganese deficiency can contribute to glucose intolerance and may be reversed by supplementation.172 A young adult with insulin-dependent diabetes who received oral manganese (3 to 5 mg per day as manganese chloride) reportedly experienced a significant fall in blood glucose, sometimes to dangerously low levels. In three other people with type 1 diabetes, manganese supplementation had no effect on blood glucose levels.173 People with type 1 diabetes wishing to supplement with manganese should do so only with a doctor’s close supervision.
Refer to label instructions
Mistletoe extract has been shown to stimulate insulin release from pancreas cells, and it may reduce diabetes symptoms.
Mistletoe extract has been shown to stimulate insulin release from pancreas cells,174 and animal research found that it reduces symptoms of diabetes.175 No research in humans has yet been published; however, given mistletoe’s worldwide reputation as a traditional remedy for diabetes, clinical trials are warranted to validate these promising preliminary findings. Traditionally, mistletoe is prepared by soaking 2 to 4 teaspoons (5 to 12 grams) of chopped mistletoe in 2 cups (500 ml) of water overnight. The mixture is drunk first thing in the morning and sweetened with honey if desired. Another batch may be left to steep during the day and drunk at bedtime.
Refer to label instructions
Olive leaf extracts have been used experimentally to lower high blood sugar in diabetic animals
Olive leaf extracts have been used experimentally to lower elevated blood-sugar levels in diabetic animals.176 These results have not been reproduced in human clinical trials.
Refer to label instructions
Quercetin may be helpful for its ability to reduce levels of sorbitol—a sugar that accumulates in cells and damages the nerves, kidneys, and eyes of people with diabetes.
Doctors have suggested that quercetin might help people with diabetes because of its ability to reduce levels of sorbitol—a sugar that accumulates in nerve cells, kidney cells, and cells within the eyes of people with diabetes and has been linked to damage to those organs.177 Clinical trials have yet to explore whether quercetin actually protects people with diabetes from nerve damage (neuropathy), nephropathy, or eye damage (retinopathy).
Refer to label instructions
Reishi may have some beneficial action in people with diabetes.
Animal studies and some very preliminary trials in humans suggest reishi may have some beneficial action in people with diabetes.178, 179
Refer to label instructions
Animal and preliminary research suggests a connection between sea buckthorn and improved measures of blood sugar control.
Animal research reports that sea buckthorn flavonoids lower blood glucose.180, 181 In a preliminary trial, children with type 1 diabetes who consumed a concentrated mixture of sea buckthorn berries and blueberries (concentration and relative proportions not stated) for two months had improved blood measures of glucose control.182 Double-blind research using sea buckthorn alone is needed to confirm these findings and to determine an effective daily amount of sea buckthorn.
Selenium, Vitamin A, Vitamin C, and Vitamin E (Diabetic Retinopathy)
Refer to label instructions
Antioxidant nutrients including selenium, vitamin A, vitamin C, and vitamin E may combat free radicals associated with diabetic retinopathy.
Because oxidation damage is believed to play a role in the development of diabetic eye damage (retinopathy), antioxidant nutrients might be protective. One doctor has administered a daily regimen of 500 mcg selenium, 800 IU vitamin E, 10,000 IU vitamin A, and 1,000 mg vitamin C for several years to 20 people with diabetic eye damage (retinopathy). During that time, 19 of the 20 people showed either improvement or no progression of their retinopathy.183 People who wish to supplement with more than 250 mcg of selenium per day should consult a healthcare practitioner.
Selenium, Vitamin A, Vitamin C, and Vitamin E
Refer to label instructions
A combination of the antioxidants selenium, vitamin A, vitamin C, and vitamin E has been shown to improve diabetic retinopathy.
Because oxidation damage is believed to play a role in the development of diabetic eye damage (retinopathy), antioxidant nutrients might be protective. One doctor has administered a daily regimen of 500 mcg selenium, 800 IU vitamin E, 10,000 IU vitamin A, and 1,000 mg vitamin C for several years to 20 people with diabetic eye damage (retinopathy). During that time, 19 of the 20 people showed either improvement or no progression of their retinopathy.184 People who wish to supplement with more than 250 mcg of selenium per day should consult a healthcare practitioner.
Refer to label instructions
People with type 1 diabetes tend to have low taurine levels, a condition that increases the risk of heart disease. Supplementing with taurine may restore levels.
Taurine is an amino acid found in protein-rich food. People with type 1 diabetes have been reported to have low blood taurine levels, a condition that increases the risk of heart disease by altering blood viscosity. Supplementing with taurine (1.5 grams per day) has restored blood taurine to normal levels and corrected the problem of blood viscosity within three months.185
Refer to label instructions
Supplementing with vitamin B12 may improve symptoms of diabetic neuropathy.
is needed for normal functioning of nerve cells. Vitamin B12 taken orally has reduced symptoms of nerve damage caused by diabetes in 39% of people studied; when given both intravenously and orally, two-thirds of people improved. In a preliminary trial, people with nerve damage due to kidney disease or to diabetes plus kidney disease received intravenous injections of 500 mcg of methylcobalamin (the main form of vitamin B12 found in the blood) three times a day for six months in addition to kidney dialysis. Nerve pain was significantly reduced and nerve function significantly improved in those who received the injections. Oral vitamin B12 up to 500 mcg three times per day is recommended by some practitioners.
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.
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