A recent study showed that taking calcium carbonate and gemifloxacin at the same time results in a significant reduction in blood levels of the drug.1 Consequently, gemifloxacin and calcium supplements should not be taken at the same time.
A review of interactions involving quinolone antibiotics indicated that supplements containing iron, when taken at the same time as gemifloxacin, might reduce absorption of the drug up to 50%.2 Consequently, gemifloxacin and supplements containing iron should not be taken at the same time.
One study showed that taking an antacid containing magnesium and aluminum ten minutes before gemifloxacin results in an 85% reduction in the absorption of the drug.3 Consequently, gemifloxacin and supplements containing magnesium should not be taken at the same time.
Potential Negative Interaction
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
1. Allen A, Vousden M, Porter A, Lewis A. Effect of Maalox on the bioavailability of oral gemifloxacin in healthy volunteers. Chemotherapy 1999;45:504–11.
2. Lode H. Evidence of different profiles of side effects and drug-drug interactions among the quinolones—the pharmacokinetic standpoint. Chemotherapy 2001;47 Suppl 3:24–31; discussion 44–8.
3. Pletz MW, Petzold P, Allen, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158–60.
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The Aisle7 knowledgebase does not contain every possible interaction.
The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2014.
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