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Health Information


Topic Contents


Drug Information

Hyoscyamine is used in the treatment of peptic ulcers and of Parkinson’s disease to reduce stiffness, tremors, and excess sweating. It acts as a drying agent in the treatment of hay fever and is also used to treat spasm and increased movement of both the intestines in irritable bowel syndrome and the bladder in urinary tract infections . Hyoscyamine is a belladonna alkaloid in a class of drugs known as anticholinergic antispasmodics.

Common brand names:

Anaspaz, Cystospaz, Levsin, Nu-Lev

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • Iron

    Absorption of ferrous citrate, an iron compound that is usually well absorbed, is reduced in individuals taking hyoscyamine;1 therefore, these two substances should not be taken at the same time.

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • Anisodus tanguticus

    The herb Anisodus tanguticus contains a chemical that has effects similar to atropine , a compound related to hyoscyamine.2 Though no human studies have investigated a possible adverse interaction between hyoscyamine and anisodus, individuals should avoid the combination until more is known.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.


1. Orrego-Matte H, Fernandez O, Mena I. Effect of anticholinergic agents on the intestinal absorption of 59 Fe ferrous citrate. Am J Dig Dis 1971;16:789-95.

2. Qicheng F. Some current study and research approaches relating to the use of plants in the traditional Chinese medicine. J Ethnopharmacol 1980;2:57-63.

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