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Complementary and Alternative Medicine - Cam

Search Health Information    Clofibrate

Topic Contents


Drug Information

Clofibrate is a drug used to lower cholesterol in people with high blood cholesterol. It is rarely used, due to the possibility of liver damage and the availability of safer, more effective drugs.

Common brand names:


Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • Vitamin B12

    Clofibrate has been reported to reduce absorption of vitamin B12.1

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Reduce Side Effects

  • Milk Thistle

    Although there have been no clinical studies, use of milk thistle (Silibum marianum) with clofibrate may theoretically lower the risk of liver side effects associated with the drug. People may take a standardized milk thistle extract supplying 70–80% silymarin at an amount of 200 mg three times per day.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • none

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.


1. Robinson C, Weigly E. Basic Nutrition and Diet Therapy. New York: Macmillan, 1984, 46-54.

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