Anemia is one of the side effects of ribavirin therapy. In a preliminary trial, supplementing with EPA partially prevented the decline in hemoglobin levels in patients with hepatitis C who were being treated with the combination of ribavirin and pegylated interferon alpha-2b.1
In a randomized trial, patients with chronic hepatitis C who were being treated with Peg-interferon-alpha 2b and ribavirin were randomly assigned to receive L-carnitine (2 grams twice a day) or no L-carnitine (control group). Compared with the control group, fewer patients in the L-carnitine group had to reduce the medication dosage or discontinue treatment because of side effects such as anemia or a decline in the white blood cell count.2
Potential Negative Interaction
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
1. Suzuki M, Inage E, Minowa K, et al. Prophylaxis for ribavirin-related anemia using eicosapentaenoic acid in chronic hepatitis C patients. Pediatr Int 2012;54:528–31.
2. Malaguarnera M, Vacante M, Giordano M, et al. L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-alpha 2b plus ribavirin. World J Gastroenterol 2011;17:4414–20.
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The Aisle7 knowledgebase does not contain every possible interaction.
The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2014.
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